Tiny Wireless Battery-Free Implant for Optogenetics Illuminates Neuron Activity in the Brain

Optogenetics method lights up neuron activity
Philipp Gutruf (left) and Jokubas Ausra and team are creating new tools for a method called optogenetics, which shines light at specific neurons in the brain to excite or suppress activity. The goal is to better understand how the brain works, allowing scientists to develop and test potential cures for illnesses such as neurodegenerative diseases. Photo credit: University of Arizona, College of Engineering)

Everything that happens in the brain is a result of neurons sending and receiving signals in complex networks that are not completely understood by scientists. These networks are what allow us to pick up a cup of coffee, laugh at a joke or stand up from a chair. When some neurons do not send and receive and signals properly, it can lead to problems such as epilepsy, depression, addiction and chronic pain.

Read more Innovative Brain Implant Reads and Stimulates Brain to Improve Parkinson’s Treatment

University of Arizona engineering researchers, led by biomedical engineering professor and Craig M. Berge Faculty Fellow Philipp Gutruf, are creating new tools for a method called optogenetics, which shines light at specific neurons in the brain to excite or suppress activity.

Optogenetics experiments are aimed at increasing understanding of how the brain works, allowing scientists to develop and test potential cures for illnesses such as neurodegenerative diseases, reports Emily Dieckman in University of Arizona News.

In a new paper published in PNAS, UArizona researchers collaborated with researchers at Northwestern University to demonstrate an untethered light delivery tool to enable seamless optogenetics in the brain.

While this technique has huge potential to treat diseases with a neurological basis, the invasive nature of the current methodology is a major stumbling block. The light source developed at the University of Arizona aims to change that, and bring us a little closer to clinical optogenetics.

“This technique means we can use optogenetics without having to penetrate the skull or brain tissue, making it much less invasive,” said Jokubas Ausra, a biomedical engineering doctoral student in the Gutruf Lab and first author of the paper.

Tiny Device, Big Results

A tiny brain implant
The wireless battery-free device, which is implanted just under the skin, is as thin as a sheet of paper and about half the diameter of a dime. (Photo credit: University of Arizona College of Engineering)

In the new paper, Gutruf and his team report on the first wireless transcranial optogenetic simulation device that can send light through the skull rather than physically penetrating the blood-brain barrier. The transcranial technique is done using a wireless and battery-free device that’s as thin as a sheet of paper and about half the diameter of a dime, implanted just under the skin.

“This is significant because when optogenetics become available for humans, we have technology that enables seamless light delivery to neurons in the brain or spine,” said Gutruf, who is also a member of the university’s BIO5 Institute. “This means we have a precursor technology that could someday help manage conditions like epilepsy or chronic pain without invasive surgery and chronic use of drugs.”

Read more Wise Therapeutics and Soterix Announce Results of Their Collaborative Study Combining Digital Therapy With Neurostimulation Device

Speeding Up Future Progress

There is still a long way to go before the technology is available for humans. In particular, progress must be made on methods for introducing light-sensitive proteins into the human brain and periphery.

“This tool allows scientists to do a wide range of experiments that were previously not possible,” Gutruf said. “These possibilities enable the scientific community to make faster progress to uncover the working principles of the brain and develop and test treatments in accurate environments. This is important for many areas – for example, enabling drug-free pain therapies to beat the opioid crisis.”

Previous articleNeuroPace Develops Smart Wearable RNS System For The Treatment of Drug-Resistant Epilepsy
Next articleLifeProof Creates Eco-Friendly Cases for Apple Products Using Ocean-Based Recycled Plastics
Sam Draper () is Online Editor at WT | Wearable Technologies specialized in the field of sports and fitness but also passionated about any new lifestyle gadget on the market. Sam can be contacted at press(at)wearable-technologies.com.